Open Heart (Aug 2022)

Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF

  • Daniela Poli,
  • Sophie Testa,
  • Corrado Lodigiani,
  • Toon Wei Lim,
  • Kevin Jones,
  • Kangning Chen,
  • Hui Li,
  • Hilary Pinnock,
  • Grzegorz Bilo,
  • Hack-Lyoung Kim,
  • Andrew Murray,
  • Bernard J Gersh,
  • Kurt Huber,
  • Robin Fox,
  • Sarah Davies,
  • James Rogers,
  • Morten Schou,
  • Xin Li,
  • Vira Tseluyko,
  • Sergey Popov,
  • Rajeev Gupta,
  • Grzegorz Opolski,
  • Preeti Pandya,
  • Bronte Ayres,
  • Milan Gupta,
  • Peter Hutchinson,
  • Phil Simmons,
  • Andrew Gallagher,
  • Michel Galinier,
  • Franck Paganelli,
  • Jens Kilian,
  • Adam Blenkhorn,
  • Mohamed Ibrahim,
  • Fernando Lanas,
  • Karen Pieper,
  • Eivind Berge,
  • M Clark,
  • Agneta Andersson,
  • Karim Ladha,
  • Bijoy Sinha,
  • Torstein Hole,
  • Dan Atar,
  • Hywel Jones,
  • R Smith,
  • Andrew Ross,
  • Emmanuel Ellie,
  • Paul Evans,
  • Yong Wang,
  • Hiroshi Ono,
  • Tadashi Nakamura,
  • Paul MacDonald,
  • Stephen Rogers,
  • Igor Sibon,
  • Simon Dobson,
  • David Fitzmaurice,
  • Jiyan Chen,
  • Neil Roberts,
  • Pierre Amarenco,
  • Nigel Hart,
  • Giancarlo Agnelli,
  • Georges Mairesse,
  • Pekka Raatikainen,
  • Oleg Sychov,
  • Yasuyuki Suzuki,
  • Bo Liu,
  • Mathieu Zuber,
  • John French,
  • Yuejin Yang,
  • Myeong-Chan Cho,
  • Julian Thompson,
  • Michael Stokes,
  • John W Eikelboom,
  • Mark Richardson,
  • John Matthews,
  • Will Murdoch,
  • Jean-Philippe Neau,
  • Freek Verheugt,
  • Ajay K Kakkar,
  • Giuseppe Ambrosio,
  • Marcin Gruchała,
  • Keith A A Fox,
  • Sunil Kumar,
  • Ruiping Zhao,
  • Patrick Carroll,
  • Masanori Kaneko,
  • Thanh Phan,
  • Ping Yang,
  • Sung-Won Jang,
  • Claire Jones,
  • Mårten Rosenqvist,
  • Johan Engdahl,
  • Debabrata Roy,
  • John Cairns,
  • Ping Chen,
  • Michael Olsen,
  • Paul Angaran,
  • David Russell,
  • Helena Dominguez,
  • Béla Merkely,
  • Joseph Berlingieri,
  • James Bennett,
  • Hugo ten Cate,
  • Hiroshi Yamaguchi,
  • Masahiro Minamoto,
  • Hiroyuki Oda,
  • Toshihiko Shiraiwa,
  • Jonathan Webster,
  • Yukihiro Koretsune,
  • Kotaro Obunai,
  • R Thompson,
  • Yong Seog Oh,
  • Giuliana Guazzaloca,
  • Giuliana Martini,
  • Marc Bonnefoy,
  • Michael Cox,
  • András Nagy,
  • Kazuki Sato,
  • Richard Davies,
  • Daisuke Ikeda,
  • Susumu Suzuki,
  • Hiroki Teragawa,
  • Koji Matsushita,
  • Ying Guo,
  • Catherine Neden,
  • Mark Pugsley,
  • Simon Cartwright,
  • Polly Jacobs,
  • Xiaoshu Cheng,
  • Daniel Nishijima,
  • Sylvia Haas,
  • Vinay Kumar,
  • Saverio Virdone,
  • Jean-Pierre Bassand,
  • Samuel Z Goldhaber,
  • Shinya Goto,
  • Frank Misselwitz,
  • Alexander G G Turpie,
  • Alison Macleod,
  • Karen Forshaw,
  • Mark Boon,
  • Stephen Miller,
  • Simon Wetherell,
  • Moustafa Moustafa,
  • Gaetano Serviddio,
  • Renato Lopes,
  • Kazuo Takei,
  • Hiroaki Nishioka,
  • Mykola Stanislavchuk,
  • C Ramesh,
  • R Kamath,
  • Stuart J Connolly,
  • Nooshin Bazargani,
  • Kevin Douglas,
  • Werner Hacke,
  • Gloria Kayani,
  • Ali Oto,
  • Hiroshi Watanabe,
  • Walter Hermans,
  • Kazuya Murata,
  • Christian Fielder Camm,
  • Marco Moia,
  • Niraj Sharma,
  • Jaeyoung Kim,
  • Walter Abhayaratna,
  • Andriy Yagensky,
  • Hosen Kiat,
  • Wilhelm Haverkamp,
  • Yang Jiao,
  • Hitoshi Kato,
  • Jindrich Spinar,
  • Daniel Theodoro,
  • Philip Cooke,
  • Paolo Golino,
  • Tetsuro Yoshida,
  • Prakash Chandwani,
  • Christine A'Court,
  • Brian Ramjattan,
  • Torbjørn Øien,
  • Toshiyuki Kobayashi,
  • Richard West,
  • Petr Jansky,
  • Seil Oh,
  • Jan Steffel,
  • Martin van Eickels,
  • Hyung-Wook Park,
  • Nam-Ho Kim,
  • Søren Rasmussen,
  • Kazuo Suzuki,
  • David Colquhoun,
  • Hiroshi Ando,
  • Simon Franklin,
  • Tae-Joon Cha,
  • Sang Cheol Bae,
  • Guosheng Fu,
  • Yoshihiro Saito,
  • Heinz Drexel,
  • Michel Martelet,
  • Joseph Mouallem,
  • Nicolas Delarche,
  • Sylvain Destrac,
  • Neil Macey,
  • Andreas Kopf,
  • Masayuki Nakano,
  • Olga Barbarash,
  • Takeshi Inoue,
  • Taro Minagawa,
  • Weihua Li,
  • John Eikelboom,
  • Hiroshi Kubo,
  • Lars Andersson,
  • D Burns,
  • Andrea Podczeck-Schweighofer,
  • Megumi Okada,
  • Massimo Volpe,
  • Takuma Aoyama,
  • Karsten Mueller,
  • Carlos Astudillo,
  • Hiroshi Takeda,
  • Peter Mayer,
  • Jung Hoon Sung,
  • Dinesh Jain,
  • Jung Han Yoon,
  • Alessandro Capucci,
  • Dongryeol Ryu,
  • Kelvin Wong,
  • Hong Euy Lim,
  • Xiaowei Yan,
  • Yusheng Zhao,
  • Yuehui Yin,
  • YUKIHIRO SETA,
  • Taek Jong Hong,
  • MASAKI SHIMOYAMA,
  • Dayi Hu,
  • Junichi Minami,
  • Yuriy Mostovoy,
  • David Foo,
  • Ramazan Topsakal,
  • Zhi-Cheng Jing,
  • Dipen Shah,
  • Kenichi Yamamoto,
  • David Coulshed,
  • Olivier Piot,
  • Ramón Corbalán,
  • Silva Severi,
  • Waldemar Myszka,
  • Mehmet Birhan Yilmaz,
  • Gi-Byoung Nam,
  • Jun Kim,
  • Harald Darius,
  • Jan-Erik Karlsson,
  • PETER VANDERGOTEN,
  • Nasser Taha,
  • Shuta Toru,
  • Jörn Nielsen,
  • Tsutomu Takagi,
  • Koji Higuchi,
  • Steen Husted,
  • Tomohiro Katsuya,
  • Frank Cools,
  • Iveta Petrova,
  • Songkwan Silaruks,
  • GÜNTER LEHMANN,
  • Frederic Casassus,
  • Bernard Crousillat,
  • Bernard Doucet,
  • Jean-Joseph Muller,
  • Grzegorz Raczak,
  • Kazuyuki Saito,
  • Anders Ostrem,
  • Chi Keong Ching,
  • KUNIHIKO YAMAMOTO,
  • John Camm,
  • Carmine Mazzone,
  • Jaemin Shim,
  • Jadwiga Nessler,
  • Jan Vercammen,
  • Marc Delforge,
  • Chong-Jin Kim,
  • Pierre Nazeyrollas,
  • Louise Lumley,
  • Paul Roome,
  • Helen Stoddart,
  • Mark Rickenbach,
  • Paul Mullen,
  • Noriyuki Nakanishi,
  • Gordon Irvine,
  • Paul Conn,
  • Kurt Lenz,
  • Richard Coates,
  • E Fisher,
  • Warwick Coulson,
  • Jiri Lastuvka,
  • Pablo García Pavía,
  • P Jhittay,
  • Philip Saunders,
  • Peter Bernhardt,
  • Wanwarang Wongcharoen,
  • Kentaro Yamamoto,
  • Hector Lucas Luciardi,
  • Harry Gibbs,
  • Marianne Brodmann,
  • Jørn Dalsgaard Nielsen,
  • Hany Ragy,
  • Matyas Keltai,
  • Jitendra Pal Singh Sawhney,
  • Janina Stepinska,
  • Elizaveta Panchenko,
  • Barry Jacobson,
  • Xavier Viñolas,
  • Pantep Angchaisuksiri,
  • Alex Parkhomenko,
  • Huaiqin Zhang,
  • Shiping Cao,
  • Daowen Wang,
  • Guizhou Tao,
  • Yingmin Chen,
  • Shenghu He,
  • Tongguo Wu,
  • Moshui Chen,
  • Longgen Xiong,
  • Praveen Jadhavm,
  • Raghava Sarma,
  • Govind Kulkarni,
  • Rasesh Atulbhai Pothiwala,
  • Mohanan Padinhare Purayil,
  • Kamaldeep Chawla,
  • Veerappa Annasaheb Kothiwale,
  • Bagirath Raghuraman,
  • Vinod Madan Vijan,
  • Jitendra Sawhney,
  • Ganapathi Bantwal,
  • Aziz Khan,
  • Ramdhan Meena,
  • Manojkumar Chopada,
  • Sunitha Abraham,
  • Vikas Bisne,
  • Govindan Vijayaraghavan,
  • Rajashekhar Durgaprasad,
  • Kartikeya Bhargava,
  • Udigala Madappa Nagamalesh,
  • Rajeeve Kumar Rajput,
  • Seishu Kanamori,
  • Koichiro Kumagai,
  • Yosuke Katsuda,
  • Keiki Yoshida,
  • Fumitoshi Toyota,
  • Yuji Mizuno,
  • Ikuo Misumi,
  • Hiroo Noguchi,
  • Shinichi Ando,
  • Tetsuro Suetsugu,
  • Susumu Adachi,
  • Kei Chiba,
  • Hiroaki Norita,
  • Makoto Tsuruta,
  • Takeshi Koyanagi,
  • Takayuki Higashi,
  • Shiro Azakami,
  • Shinichiro Komaki,
  • Kenshi Kumeda,
  • Takashi Murayama,
  • Jun Matsumura,
  • Yurika Oba,
  • Ryuji Sonoda,
  • Kazuo Goto,
  • Kotaro Minoda,
  • Yoshikuni Haraguchi,
  • Hisakazu Suefuji,
  • Hiroo Miyagi,
  • Tsugihiro Nakamura,
  • Hidekazu Nandate,
  • Ryuji Zaitsu,
  • Yoshihisa Fujiura,
  • Akira Yoshimura,
  • Hiroyuki Numata,
  • Jun Ogawa,
  • Yasuyuki Kamogawa,
  • Kinshiro Murakami,
  • Yutaka Wakasa,
  • Masanori Yamasawa,
  • Hiromitsu Maekawa,
  • Sumihisa Abe,
  • Hajime Kihara,
  • Satoru Tsunoda,
  • Katsumi Saito,
  • Hiroki Tachibana,
  • Ichiro Oba,
  • Takashi Kuwahata,
  • Satoshi Higa,
  • Masamichi Gushiken,
  • Takuma Eto,
  • Hidetoshi Chibana,
  • Kazuaki Fujisawa,
  • Yuhei Shiga,
  • Hirokuni Sumi,
  • Toshihisa Nagatomo,
  • Yoshihiko Atsuchi,
  • Toshiro Nagoshi,
  • Kazuhisa Sanno,
  • Fumihiro Hoshino,
  • Naoto Yokota,
  • Masahiro Kameko,
  • Toshifumi Tabuchi,
  • Munesumi Ishizawa,
  • Yoshitake Fujiura,
  • Taku Seto,
  • Tetsu Iwao,
  • Norio Ishioka,
  • Koichi Oshiro,
  • Keizo Tsuchida,
  • Yutaka Hatori,
  • Motoshi Takeuchi,
  • Hiroto Takezawa,
  • Shinjiro Nagano,
  • Masaaki Iwaki,
  • Yuichiro Nakamura,
  • Naomasa Miyamoto,
  • Toshifumi Taguchi,
  • Ko Ashida,
  • Naoto Yoshizawa,
  • Jun Agata,
  • Seishiro Matsukawa,
  • Osamu Arasaki,
  • Shuji Fukuoka,
  • Hirofumi Murakami,
  • Kazuya Mishima,
  • Yoshiki Hata,
  • Ichiro Sakuma,
  • Ichiro Takamura,
  • Mitsuyuki Akutsu,
  • Toshihide Unoki,
  • Yoshinori Go,
  • Makoto Ikemura,
  • Shoji Morii,
  • Shigeru Marusaki,
  • Hideo Doi,
  • Mitsuru Tanaka,
  • Takaaki Kusumoto,
  • Shigeo Kakinoki,
  • Chiga Ogurusu,
  • Masami Nakatsuka,
  • Yutaka Kitami,
  • Yoichi Nakamura,
  • Hiroshi Oda,
  • Rikimaru Oyama,
  • Masato Ageta,
  • Teruaki Mita,
  • Kazuhiko Nagao,
  • Takafumi Mito,
  • Mitsunori Abe,
  • Masako Fujii,
  • Makoto Okawa,
  • Tsuneo Fujito,
  • Toshiya Taniguchi,
  • Tenei Ko,
  • Mizuho Imamaki,
  • Masahiro Akiyama,
  • Takashi Ueda,
  • Hironori Odakura,
  • Masahiko Inagaki,
  • Yoshiki Katsube,
  • Atsuyuki Nakata,
  • Shinobu Tomimoto,
  • Mitsuhiro Shibuya,
  • Kenichiro Ito,
  • Masahiro Matsuta,
  • Motoyuki Ishiguro,
  • Masamichi Wada,
  • Hiroaki Mukawa,
  • Masato Mizuguchi,
  • Fumio Okuda,
  • Teruaki Kimura,
  • Kuniaki Taga,
  • Masaaki Techigawara,
  • Morio Igarashi,
  • Toshihiko Seo,
  • Shinya Hiramitsu,
  • Hiroaki Hosokawa,
  • Mitsumoto Hoshiai,
  • Michitaka Hibino,
  • Koichi Miyagawa,
  • Hideki Horie,
  • Nobuyoshi Sugishita,
  • Yukio Shiga,
  • Akira Soma,
  • Kazuo Neya,
  • Kunio Akahane,
  • Saori Matsui,
  • Hirofumi Kanda,
  • Shiro Nagasaka,
  • Atsushi Taguchi,
  • Akiko Miyashita,
  • Hiroki Sasaguri,
  • Jin Nariyama,
  • Taketo Hatsuno,
  • Takash Iwase,
  • Kazuya Kawai,
  • Tomobumi Kotani,
  • Tsuyoshi Tsuji,
  • Hirosumi Sakai,
  • Kiyoshi Nishino,
  • Kenichi Ikeda,
  • Kazuo Maeda,
  • Tomohiro Shinozuka,
  • Koichi Kawakami,
  • Hiromichi Kitazumi,
  • Mamoru Hamaoka,
  • Jisho Kojima,
  • Akitoshi Sasaki,
  • Yoshihiro Tsuchiya,
  • Tetsuo Betsuyaku,
  • Masaaki Honda,
  • Koichi Hasegawa,
  • Takao Baba,
  • Kazuaki Mineoi,
  • Toshihiko Koeda,
  • Kunihiko Hirasawa,
  • Toshihide Kumazaki,
  • Akira Nakagomi,
  • Eiji Otaki,
  • Takashi Shindo,
  • Hiroyoshi Hirayama,
  • Chikako Sugimoto,
  • Takashi Yamagishi,
  • Ichiro Mizuguchi,
  • Kazunori Sezaki,
  • Isamu Niwa,
  • Ken Takenaka,
  • Osamu Iiji,
  • Koichi Taya,
  • Hitoshi Kitazawa,
  • Samu Ueda,
  • Hirokazu Kakuda,
  • Takuya Ono,
  • Seizo Oriso,
  • Junya Kamata,
  • Toshihiko Nanke,
  • Itaru Maeda,
  • Yoshifusa Matsuura,
  • Yasuyuki Maruyama,
  • Hajime Horie,
  • Tetsutaro Kito,
  • Hiroshi Asano,
  • Masaichi Nakamura,
  • Takashi Washizuka,
  • Tomoki Yoshida,
  • Masato Sawano,
  • Shinichi Arima,
  • Hidekazu Arai,
  • Hisanori Shinohara,
  • Hiroyuki Takai,
  • Nobufusa Furukawa,
  • Akira Ota,
  • Kenji Aoki,
  • Taku Yamamoto,
  • Takeaki Kasai,
  • Shunji Suzuki,
  • Shu Suzuki,
  • Nitaro Shibata,
  • Masayuki Watanabe,
  • Yosuke Nishihata,
  • Toru Arino,
  • Masaki Okuyama,
  • Tetsushi Wakiyama,
  • Tomoko Kato,
  • Yasuo Sasagawa,
  • Takeshi Tana,
  • Yoshihito Hayashi,
  • Shinichi Hirota,
  • Yukihiko Abe,
  • Hirohide Uchiyama,
  • Shuichi Tohyo,
  • Naoto Hanazono,
  • Seiichi Miyajima,
  • Hisashi Shimono,
  • Yasunobu Shozawa,
  • Yawara Niijima,
  • Osamu Murai,
  • Hideko Inaba,
  • Katsumasa Nomura,
  • Masatsugu Nozoe,
  • Toshiyuki Furukawa,
  • Nobuhisa Ito,
  • Shunichi Nagai,
  • Kiyoharu Sato,
  • Shiro Nakahara,
  • Yujin Shimoyama,
  • Naoko Ohara,
  • Teruhiko Kozuka,
  • Hideaki Okita,
  • Masato Endo,
  • Tsutomu Goto,
  • Makoto Hirose,
  • Emiko Nagata,
  • Toshizumi Mori,
  • Shuichi Seki,
  • Katsuhiro Okamoto,
  • Osamu Moriai,
  • Yoko Emura,
  • Tsuyoshi Fukuda,
  • Haruhiko Date,
  • Shuichi Kawakami,
  • Sho Nagai,
  • Yuya Ueyama,
  • Tetsuro Fudo,
  • Mitsuru Imaizumi,
  • Takuo Ogawa,
  • Shunsuke Take,
  • Hideo Ikeda,
  • Norihiko Sakamoto,
  • Kiyomitsu Ikeoka,
  • Nobuo Wakaki,
  • Masatake Abe,
  • Junji Doiuchi,
  • Tetsuya Kira,
  • Masato Tada,
  • Ken Tsuzaki,
  • Naoya Miura,
  • Yasuaki Fujisawa,
  • Wataru Furumoto,
  • Akinori Fujisawa,
  • Ryosai Nakamura,
  • Hiroyasu Komatsu,
  • Rei Fujiki,
  • Shuichi Kawano,
  • Keijiro Nishizawa,
  • Yoji Kato,
  • Junya Azuma,
  • Kiyoshi Yasui,
  • Toshio Amano,
  • Yasuhiro Sekine,
  • Tatsuo Honzawa,
  • Yuichiro Koshibu,
  • Yasuhide Sakamoto,
  • Shingo Miyaguchi,
  • Kojuro Morishita,
  • Yasuko Samejima,
  • Toyoshi Sasaki,
  • Fumiko Iseki,
  • Hiroshi Kano,
  • Yoichi Takagi,
  • Yoko Onuki Pearce,
  • Takayuki Fukui,
  • Toru Nakayama,
  • Hideaki Kanai,
  • Yoshiyuki Kawano,
  • Tetsuji Ino,
  • Hironori Miyoshi,
  • Yasufumi Miyamoto,
  • Masahito Shigekiyo,
  • Shimato Ono,
  • Yutaka Okamoto,
  • Satoshi Ubukata,
  • Kojiro Kodera,
  • Tatsuo Oriuchi,
  • Naoki Matsumoto,
  • Koichi Inagaki,
  • Atsushi Iseki,
  • Tomohiro Yoshida,
  • Toshihiro Goda,
  • Tsukasa Katsuki,
  • Atsushi Sato,
  • Etsuo Mori,
  • Toshio Tsubokura,
  • Hiroshi Shudo,
  • Shunichi Fujimoto,
  • Yoshiyuki Furukawa,
  • Hiroshi Hosokawa,
  • Jun Narumi,
  • Kiichiro Yamamoto,
  • Masaki Owari,
  • Takuya Inakura,
  • Takafumi Anno,
  • Kazuyuki Shirakawa,
  • Tan Yuyang,
  • Hui Nam Park,
  • Woo-Shik Kim,
  • HyeYoung Lee,
  • Dae Hyeok Kim,
  • Dae-Kyeong Kim,
  • Dong Ju Choi,
  • Hui-Kyung Jeon,
  • Dong-Gu Shin,
  • Sang Weon Park,
  • Hoon Ki Park,
  • Sang-Jin Han,
  • Young Keun On,
  • JaeJin Kwak,
  • Seong Hoon Park,
  • Kee-Sik Kim,
  • Byung Chun Jung,
  • Gyo-Seung Hwang,
  • Sakda Rungaramsin,
  • Peerapat Katekangplu,
  • Porames Khunrong,
  • Thanita Bunyapipat,
  • Pinij Kaewsuwanna,
  • Khanchai Siriwattana,
  • Waraporn Tiyanon,
  • Supalerk Pattanaprichakul,
  • Khanchit Likittanasombat,
  • Doungrat Cholsaringkarl,
  • Warangkana Boonyapisit,
  • Sirichai Cheewatanakornkul,
  • Pisit Hutayanon,
  • Seksan Chawanadelert,
  • Pairoj Chattranukulchai,
  • Boonsert Chatlaong,
  • Yingsak Santanakorn,
  • Khompiya Kanokphatcharakun,
  • Piya Mongkolwongroj,
  • Sasivimon Jai-Aue,
  • Ongkarn Komson,
  • Armagan Altun,
  • Ali Aydinlar,
  • Zeki Ongen,
  • Sadik Acikel,
  • Durmus Yildiray Sahin,
  • Ozcan Yilmaz,
  • Hasan Pekdemir,
  • Mesut Demir,
  • Murat Sucu,
  • Levent Sahiner,
  • Murat Ersanli,
  • Ertugrul Okuyan,
  • Dursun Aras,
  • Florencia Rolandi,
  • Adrian Cesar Ingaramo,
  • Gustavo Alberto Sambadaro,
  • Vanina Fernandez Caputi,
  • Hector Luciardi,
  • Sofia Graciela Berman,
  • Pablo Dragotto,
  • Andres Javier Kleiban,
  • Nestor Centurion,
  • Ricardo Dario Dran,
  • Javier Egido,
  • Matias Jose Fosco,
  • Victor Alfredo Sinisi,
  • Luis Rodolfo Cartasegna,
  • Oscar Gomez Vilamajo,
  • Jose Luis Ramos,
  • Sonia Sassone,
  • Gerardo Zapata,
  • Diego Conde,
  • Guillermo Giacomi,
  • Alberto Alfredo Fernandez,
  • Mario Alberto Berli,
  • Fabian Ferroni,
  • Jefferson Jaber,
  • Luciana Vidal Armaganijan,
  • André Steffens,
  • José Márcio Ribeiro,
  • Marcelo Silveira Teixeira,
  • Paulo Rossi,
  • Leonardo Pires,
  • Daniel Moreira,
  • Luiz Bodanese,
  • Marcelo Westerlund Montera,
  • Jamil Abdalla Saad,
  • Euler Roberto Manenti,
  • Alexandre Negri,
  • Carlos Moncada,
  • Dalton Precoma,
  • Fernando Roquette,
  • Gilmar Reis,
  • Estêvão Lanna Figueiredo,
  • Roberto Vieira Botelho,
  • Helius Carlos Finimundi,
  • Adriano Kochi,
  • Fábio Alban,
  • Rogério Tadeu Tumelero,
  • Lilia Maia,
  • Humberto Montecinos,
  • Martín Larico Gómez,
  • Carlos Conejeros,
  • Patricio Marin Cuevas,
  • Alejandro Forero,
  • Claudio Bugueño Gutiérrez,
  • Juan Aguilar,
  • Sergio Potthoff Cardenas,
  • German Eggers,
  • Cesar Houzvic,
  • Carlos Rey,
  • Germán Arriagada,
  • Gustavo Charme Vilches,
  • Raul Leal Cantu,
  • Ricardo Cabrera Jardines,
  • Nilda Espinola Zavaleta,
  • Enrique Lopez Rosas,
  • Gerardo Pozas,
  • Ernesto Cardona Muñoz,
  • Norberto Matadamas Hernandez,
  • Adolfo Leyva Rendon,
  • Norberto Garcia Hernandez,
  • David Lopez Villezca,
  • Carlos Hernandez Herrera,
  • Rodolfo Gaona Rodriguez,
  • Efrain Villeda Espinosa,
  • David Flores Martinez,
  • Jose Velasco Barcena,
  • Omar Fierro Fierro,
  • Ignacio Rodriguez Briones,
  • Humberto Alvarez Lopez,
  • Rafael Olvera Ruiz,
  • Roxana Reyes Sanchez,
  • Roberto Arriaga Nava,
  • Pedro Fajardo Campos,
  • Mario Benavides Gonzalez,
  • Claus Hagn,
  • Johannes Foechterle,
  • Michael Winkler,
  • Bruno Schneeweiss,
  • Alfons Gegenhuber,
  • Wilfried Lang,
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  • Joan Bayo iLlibre,
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DOI
https://doi.org/10.1136/openhrt-2022-002038
Journal volume & issue
Vol. 9, no. 2

Abstract

Read online

Objective While greater body mass index (BMI) is associated with increased risk of developing atrial fibrillation (AF), the impact of BMI on outcomes in newly diagnosed AF is unclear. We examine the influence of BMI on outcomes and whether this is modified by sex and evaluate the effect of non-vitamin K oral anticoagulants (NOACs) in patients with high BMI.Methods GARFIELD-AF is a prospective registry of 52 057 newly diagnosed AF patients. The study population comprised 40 482 participants: 703 underweight (BMI <18.5 kg/m2), 13 095 normal (BMI=18.5–24.9 kg/m2), 15 043 overweight (BMI=25.0–29.9 kg/m2), 7560 obese (BMI=30.0–34.9 kg/m2) and 4081 extremely obese (BMI ≥35.0 kg/m2). Restricted cubic splines quantified the association of BMI with outcomes. Comparative effectiveness of NOACs and vitamin K antagonists (VKAs) by BMI was performed using propensity score overlap-weighted Cox models.Results The median age of participants was 71.0 years (Q1; Q3 62.0; 78.0), and 55.6% were male. Those with high BMI were younger, more often had vascular disease, hypertension and diabetes. Within 2-year follow-up, a U-shaped relationship between BMI and all-cause mortality was observed, with BMI of ~30 kg/m2 associated with the lowest risk. The association with new/worsening heart failure was similar. Only low BMI was associated with major bleeding and no association emerged for non-haemorrhagic stroke. BMI was similarly associated with outcomes in men and women. BMI did not impact the lower rate of all-cause mortality of NOACs compared with VKAs.Conclusions In the GARFIELD-AF registry, underweight and extremely obese AF patients have increased risk of mortality and new/worsening heart failure compared with normal or obese patients.