CHIMIA (Jun 1997)

Application of Enzymes in Industrial Organic Synthesis

  • Hans E. Schoemaker,
  • Wilhelmus H.J. Boesten,
  • Quirinus B. Broxterman,
  • Eric C. Roos,
  • Bernard Kaptein,
  • Will J.J. van den Tweel,
  • Johan Kamphuis,
  • Emmo M. Meijer,
  • Floris P.J.T. Rutjes

Journal volume & issue
Vol. 51, no. 6

Abstract

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Aminopeptidase- and amidase-based methods for the production of enantiomerically pure amino acids, intermediates for pharmaceuticals and agrochemicals, are discussed. Furthermore, enzymatic syntheses of the dipeptide sweetener aspartame and semisynthetic antibiotics (such as ampicillin, amoxicillin, cephalexin, and cefadroxil) are highlighted.