A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation

Yavor Hadzhiev; Haseeb K. Qureshi; Lucy Wheatley; Ledean Cooper; Aleksandra Jasiulewicz; Huy Van Nguyen; Joseph W. Wragg; Divyasree Poovathumkadavil; Sascha Conic; Sarah Bajan; Attila Sik; György Hutvàgner; Làszlò Tora; Agnieszka Gambus; John S. Fossey; Ferenc Müller

doi:10.1038/s41467-019-08487-5

Nature Communications (Feb 2019)

A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation

Yavor Hadzhiev,
Haseeb K. Qureshi,
Lucy Wheatley,
Ledean Cooper,
Aleksandra Jasiulewicz,
Huy Van Nguyen,
Joseph W. Wragg,
Divyasree Poovathumkadavil,
Sascha Conic,
Sarah Bajan,
Attila Sik,
György Hutvàgner,
Làszlò Tora,
Agnieszka Gambus,
John S. Fossey,
Ferenc Müller

Affiliations

Yavor Hadzhiev: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Haseeb K. Qureshi: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Lucy Wheatley: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Ledean Cooper: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Aleksandra Jasiulewicz: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Huy Van Nguyen: School of Chemistry, University of Birmingham
Joseph W. Wragg: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Divyasree Poovathumkadavil: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Sascha Conic: Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR7104, Centre National de la Recherche Scientifique
Sarah Bajan: Faculty of Engineering and Information Technology, Biomedical Engineering School, University of Technology
Attila Sik: Institute of Transdisciplinary Discoveries, Institute of Physiology, Medical School, University of Pecs
György Hutvàgner: Faculty of Engineering and Information Technology, Biomedical Engineering School, University of Technology
Làszlò Tora: Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR7104, Centre National de la Recherche Scientifique
Agnieszka Gambus: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
John S. Fossey: School of Chemistry, University of Birmingham
Ferenc Müller: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham

DOI: https://doi.org/10.1038/s41467-019-08487-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Transcription is globally repressed in early stage of embryo development, but a set of genes including pri-miR-430 and zinc finger genes is known to escape the repression. Here the authors image the very first transcriptional activities in the living zebra fish embryo, demonstrating a cell cycle-coordinated polymerase II transcription compartment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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