Nature Communications (Feb 2020)
Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
- Yue Zhao,
- Meng-Fei Zhao,
- Shan Jiang,
- Jing Wu,
- Jia Liu,
- Xian-Wen Yuan,
- Di Shen,
- Jing-Zi Zhang,
- Nan Zhou,
- Jian He,
- Lei Fang,
- Xi-Tai Sun,
- Bin Xue,
- Chao-Jun Li
Affiliations
- Yue Zhao
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Meng-Fei Zhao
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Shan Jiang
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Jing Wu
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Jia Liu
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Xian-Wen Yuan
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Di Shen
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Jing-Zi Zhang
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Nan Zhou
- MOE Key Laboratory of Model Animals for Disease Study, Department of Hepatobiliary Surgery & Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Jian He
- MOE Key Laboratory of Model Animals for Disease Study, Department of Hepatobiliary Surgery & Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Lei Fang
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- Xi-Tai Sun
- MOE Key Laboratory of Model Animals for Disease Study, Department of Hepatobiliary Surgery & Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Bin Xue
- Core Laboratory, Sir Run Run Hospital, Nanjing Medical University
- Chao-Jun Li
- State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & Model Animal Research Center, Nanjing University
- DOI
- https://doi.org/10.1038/s41467-020-14450-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Extracellular vesicles (EVs) containing miRNAs or proteins can coordinate metabolic responses between tissues. Here the authors demonstrate that during lipid overload, the liver secretes miRNA-containing EVs through a Ggpps-Rab27 dependent mechanism, which controls adipose tissue lipid storage capacity.
