Lymphoproliferative Syndrome in Pediatrist and Infectiologist Practice

Abstract

Chronic Epstein-Barr virus infection (CEBVI) is the frequent infectious cause of lymphoproliferative syndrome (LPS) in children. Purpose: To characterize the most informative CEBVI diagnostic criteria in children according to age and disease form. Materials and Methods: 168 children in age from 3 to 7 (116) and from 7 to 14 years old (52) with CEBVI (70) and chlamydiosis mixed CEBVI (98) were examined. Results: Antenatal, intranatal and postnatal risk groups in all patients were exposed. LPS was detected in 100% children and characterized by combination of generalized lymphadenopathy, hepatomegaly, splenomegaly with palatine and pharyngeal tonsil hypertrophy. Except LPS, CEBVI syndromal model was included intoxication syndrome, respiratory and gastrointestinal tracts, central nervous system (CNS), cardiovascular system affection and arthralgia syndrome. CEBI in young children was characterized by frequent risk groups, palatine tonsil hypertrophy, hepatomegaly, pharyngotonsillitis and CNS affection. In patients with mixed CEBVI, high frequency of risk groups, pharyngeal tonsil hypertrophy, hepatomegaly, splenomegaly, respiratory and gastrointestinal tract, CNS pathology was detected.Summary: Risk groups and clinical symptoms of CEBVI are the indication for ELISA and PCR examination.

Keywords

• lymphoproliferative syndrome
• epstein-barr virus infection
• children