(9S,13R,14S)-7,8-Didehydro-4-(4-fluorobenzyloxy)-3,7-dimethoxy-17-methylmorphinan-6-one sesquihydrate

Abstract

In the title sinomenine derivative, C26H28FNO4·1.5H2O, the dihedral angle between the two aromatic rings is 55.32 (6)°. The N-containing ring has an approximate chair conformation, while other two rings have approximate envelope and half-chair conformations. One water molecule is located on a twofold symmetry axis. In the crystal, the water molecules form O—H...O and O—H...N hydrogen bonds, bridging symmetry-related main molecules.