Nature Communications (Jun 2018)
SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity
- Fan Yao,
- Zhicheng Zhou,
- Jongchan Kim,
- Qinglei Hang,
- Zhenna Xiao,
- Baochau N. Ton,
- Liang Chang,
- Na Liu,
- Liyong Zeng,
- Wenqi Wang,
- Yumeng Wang,
- Peijing Zhang,
- Xiaoyu Hu,
- Xiaohua Su,
- Han Liang,
- Yutong Sun,
- Li Ma
Affiliations
- Fan Yao
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Zhicheng Zhou
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Jongchan Kim
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Qinglei Hang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Zhenna Xiao
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Baochau N. Ton
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Liang Chang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Na Liu
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Liyong Zeng
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Wenqi Wang
- Department of Developmental and Cell Biology, University of California
- Yumeng Wang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Peijing Zhang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xiaoyu Hu
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xiaohua Su
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Han Liang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Yutong Sun
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Li Ma
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-04620-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Regulation of Yes-associated protein (YAP) through the Hippo pathway is well established, but its Hippo-independent regulation remains to be elucidated. Here, the authors show that non-proteolytic ubiquitination presents another means of YAP regulation, promoting its nuclear localization and activity.
