ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS

Abstract

Abstract. The study considers some aspects of pathogenetic mechanisms underlying blood eosinophilic reactions developing in pulmonary tuberculosis, taking into account some novel data obtained by means of modern immunological techniques. It was revealed that IL-5 is among key factors determining eosinophilic reactions of blood following infection with M. tuberculosis. Blood serum IL-5 concentrations proved to be significantly higher in patients with tuberculosis accompanied by eosinophilia. In these cases, eotaxin is a chemokine, which selectively acts upon eosinophilic cells. Its effects include prolonged persistence of eosinophils in bloodstream, along with initiation of eosinophil adherence to vascular endothelium, thus enabling subsequent migration of eosinophilic leukocytes to the foci of specific granulomatous inflammation. (Med. Immunol., 2011, vol. 13, N 2-3, pp 273-278)

Keywords

• lung tuberculosis
• eosinophilia
• cytokines