Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant

Zaid Muhammad; Phoebe W. Brown; Larema Babazau; Abdulrahman I. Alkhamis; Baba W. Goni; Haruna A. Nggada; Kefas M. Mbaya; Selina Wray; Isa H. Marte; Celeste M. Karch; Louise C. Serpell; Mahmoud B. Maina

Stem Cell Research (Oct 2024)

Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant

Zaid Muhammad,
Phoebe W. Brown,
Larema Babazau,
Abdulrahman I. Alkhamis,
Baba W. Goni,
Haruna A. Nggada,
Kefas M. Mbaya,
Selina Wray,
Isa H. Marte,
Celeste M. Karch,
Louise C. Serpell,
Mahmoud B. Maina

Affiliations

Zaid Muhammad: Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK; Biomedical Science Research and Training Centre, Yobe State University, Damaturu, Yobe State, Nigeria; Department of Human Physiology, College of Medical Sciences, Yobe State University, Damaturu, Yobe State, Nigeria
Phoebe W. Brown: Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK
Larema Babazau: Biomedical Science Research and Training Centre, Yobe State University, Damaturu, Yobe State, Nigeria; Yobe State University Teaching Hospital Damaturu, Yobe State, Nigeria
Abdulrahman I. Alkhamis: Biomedical Science Research and Training Centre, Yobe State University, Damaturu, Yobe State, Nigeria; Department of Human Physiology, College of Medical Sciences, Yobe State University, Damaturu, Yobe State, Nigeria; Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Baba W. Goni: Biomedical Science Research and Training Centre, Yobe State University, Damaturu, Yobe State, Nigeria; Yobe State University Teaching Hospital Damaturu, Yobe State, Nigeria; Department of Medicine, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, Nigeria
Haruna A. Nggada: Department of Human Pathology, University of Maiduguri, Maiduguri, Borno State, Nigeria
Kefas M. Mbaya: Department of Surgery, University of Maiduguri Teaching Hospital, Maiduguri, Borno State, Nigeria
Selina Wray: Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, UK
Isa H. Marte: Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Borno State, Nigeria
Celeste M. Karch: Department of Psychiatry and Knight Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, USA
Louise C. Serpell: Biomedical Science Research and Training Centre, Yobe State University, Damaturu, Yobe State, Nigeria
Mahmoud B. Maina: Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK; Biomedical Science Research and Training Centre, Yobe State University, Damaturu, Yobe State, Nigeria; Corresponding author.

Journal volume & issue: Vol. 80
p. 103503

Abstract

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Genetic backgrounds influence cellular phenotypes, drug responses, and health outcomes, yet most human iPSC lines are derived from individuals of European descent, with lines from indigenous Africans particularly scarce. Addressing this gap, we generated iPSCs from dermal fibroblasts of a healthy 60-year-old indigenous Nigerian male of the Babur ethnic group using Sendai virus. The iPSC line displayed a normal karyotype, was characterized for pluripotency markers and differentiated into neural progenitor cells and astrocytes. To enhance African representation in research, this iPSC line will be available to the scientific community, with ongoing efforts focused on creating an open-access African iPSC biobank.Resource Table:

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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