Journal of Inflammation Research (Jun 2022)
A Retrospective Analysis of Clinical Features and Treatment of the Inflammatory Bowel Disease in China
Abstract
Su’e Shao,1 Meifang Huang,2 Heng Zhang,1 Gangqiang Peng,1 Min Song,1 Jing Liu,1 Dan Xu1 1Department of Gastroenterology, The Central Hospital of Wuhan, Wuhan, People’s Republic of China; 2Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of ChinaCorrespondence: Meifang Huang, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, No. 169 East Lake Road, Wuchang District, Wuhan, Hubei, 430061, People’s Republic of China, Tel +86-13307110223, Email [email protected] Heng Zhang, Department of Gastroenterology, the Central Hospital of Wuhan, No. 26 Shengli Street, Jiang’an District, Wuhan, Hubei, 430014, People’s Republic of China, Tel +86-18627886610, Email [email protected]: To retrospectively collect and analyze demographic information as well as symptoms, laboratory results, endoscopic and pathologic findings, and treatment of ulcerative colitis (UC) and Crohn’s disease (CD) patients in Wuhan, China.Methods: Patients who were diagnosed as inflammatory bowel disease (IBD) and hospitalized from January 2012 to December 2017 were enrolled in this study. The clinical characteristics including symptoms, laboratory results, and treatment were reviewed and analyzed.Results: Totally 821 cases were screened, and finally 430 UC patients and 286 CD patients were selected and enrolled in this study. The most common symptom in UC patients was bloody stool (90.7%) followed by diarrhea (87.7%), mucus in stool (72.1%), and abdominal pain (66.3%), which were significantly different from those of CD patients (P < 0.01). In contrast, the most common symptom in CD patients was abdominal pain (80.0%) followed by diarrhea (58.4%), bloody stool (27.6%), and fever (18.2%). Erythrocyte sedimentation, C-reactive protein, and platelets were significantly increased, while hemoglobin was decreased, in the moderately or highly active IBD. The percentage of positive perinuclear anti-neutrophil cytoplasmic antibody was significantly higher in UC patients (31.1%) than that in CD patients (4.8%, P < 0.001), while the percentage of positive anti-intestinal goblet cell antibody was significantly higher in CD patients (23.1%) than that in UC patients (14.9%, P = 0.037).Conclusion: The findings of the current study may provide evidence-based information for Chinese gastroenterologists to treat IBD more effectively in the future.Keywords: inflammatory bowel disease, Crohn’s disease, ulcerative colitis