Antimicrobial Properties of <i>Apis mellifera</i>’s Bee Venom

Hesham El-Seedi; Aida Abd El-Wahed; Nermeen Yosri; Syed Ghulam Musharraf; Lei Chen; Moustafa Moustafa; Xiaobo Zou; Saleh Al-Mousawi; Zhiming Guo; Alfi Khatib; Shaden Khalifa

doi:10.3390/toxins12070451

Toxins (Jul 2020)

Antimicrobial Properties of <i>Apis mellifera</i>’s Bee Venom

Hesham El-Seedi,
Aida Abd El-Wahed,
Nermeen Yosri,
Syed Ghulam Musharraf,
Lei Chen,
Moustafa Moustafa,
Xiaobo Zou,
Saleh Al-Mousawi,
Zhiming Guo,
Alfi Khatib,
Shaden Khalifa

Affiliations

Hesham El-Seedi: International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
Aida Abd El-Wahed: Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt
Nermeen Yosri: Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt
Syed Ghulam Musharraf: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Lei Chen: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Moustafa Moustafa: Department of Chemistry, Faculty of Science, University of Kuwait, Safat 13060, Kuwait
Xiaobo Zou: School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Saleh Al-Mousawi: Department of Chemistry, Faculty of Science, University of Kuwait, Safat 13060, Kuwait
Zhiming Guo: School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Alfi Khatib: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang 25200, Malaysia
Shaden Khalifa: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91 Stockholm, Sweden

DOI: https://doi.org/10.3390/toxins12070451
Journal volume & issue: Vol. 12, no. 7
p. 451

Abstract

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Bee venom (BV) is a rich source of secondary metabolites from honeybees (Apis mellifera L.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds contribute to the venom’s observed biological functions as per its anti-inflammatory and anticancer effects. The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The synergistic therapeutic interactions of BV with antibiotics has been reported. The synergistic effect contributes to a decrease in the loading and maintenance dosage, a decrease in the side effects of chemotherapy, and a decrease in drug resistance. To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of this review is to address the antimicrobial properties of BV and its compounds.

Published in Toxins

ISSN: 2072-6651 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/toxins/

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