Synthetic cytokine receptors transmit biological signals using artificial ligands

Erika Engelowski; Artur Schneider; Manuel Franke; Haifeng Xu; Ramona Clemen; Alexander Lang; Paul Baran; Christian Binsch; Birgit Knebel; Hadi Al-Hasani; Jens M. Moll; Doreen M. Floß; Philipp A. Lang; Jürgen Scheller

doi:10.1038/s41467-018-04454-8

Nature Communications (May 2018)

Synthetic cytokine receptors transmit biological signals using artificial ligands

Erika Engelowski,
Artur Schneider,
Manuel Franke,
Haifeng Xu,
Ramona Clemen,
Alexander Lang,
Paul Baran,
Christian Binsch,
Birgit Knebel,
Hadi Al-Hasani,
Jens M. Moll,
Doreen M. Floß,
Philipp A. Lang,
Jürgen Scheller

Affiliations

Erika Engelowski: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University
Artur Schneider: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University
Manuel Franke: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University
Haifeng Xu: Institute of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University
Ramona Clemen: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University
Alexander Lang: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University
Paul Baran: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University
Christian Binsch: Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University
Birgit Knebel: Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University
Hadi Al-Hasani: Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University
Jens M. Moll: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University
Doreen M. Floß: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University
Philipp A. Lang: Institute of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University
Jürgen Scheller: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University

DOI: https://doi.org/10.1038/s41467-018-04454-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Cytokine-induced signaling acts as an ON/OFF switch dependent on the presence of ligands. Here the authors construct synthetic cytokine receptors responsive to synthetic ligands able to activate canonical signaling pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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