Nature Communications (Aug 2018)
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
- S. N. Gettinger,
- J. Choi,
- N. Mani,
- M. F. Sanmamed,
- I. Datar,
- Ryan Sowell,
- Victor Y. Du,
- E. Kaftan,
- S. Goldberg,
- W. Dong,
- D. Zelterman,
- K. Politi,
- P. Kavathas,
- S. Kaech,
- X. Yu,
- H. Zhao,
- J. Schlessinger,
- R. Lifton,
- D. L. Rimm,
- L. Chen,
- R. S. Herbst,
- K. A. Schalper
Affiliations
- S. N. Gettinger
- Medical Oncology and Yale Cancer Center
- J. Choi
- Department of Genetics, Yale School of Medicine
- N. Mani
- Department of Pathology, Yale School of Medicine
- M. F. Sanmamed
- Immunobiology, Yale School of Medicine
- I. Datar
- Department of Pathology, Yale School of Medicine
- Ryan Sowell
- Immunobiology, Yale School of Medicine
- Victor Y. Du
- Immunobiology, Yale School of Medicine
- E. Kaftan
- Medical Oncology and Yale Cancer Center
- S. Goldberg
- Medical Oncology and Yale Cancer Center
- W. Dong
- Department of Genetics, Yale School of Medicine
- D. Zelterman
- Yale School of Public Health
- K. Politi
- Medical Oncology and Yale Cancer Center
- P. Kavathas
- Immunobiology, Yale School of Medicine
- S. Kaech
- Immunobiology, Yale School of Medicine
- X. Yu
- Yale School of Public Health
- H. Zhao
- Department of Genetics, Yale School of Medicine
- J. Schlessinger
- Department of Pharmacology, Yale School of Medicine
- R. Lifton
- Department of Genetics, Yale School of Medicine
- D. L. Rimm
- Medical Oncology and Yale Cancer Center
- L. Chen
- Immunobiology, Yale School of Medicine
- R. S. Herbst
- Medical Oncology and Yale Cancer Center
- K. A. Schalper
- Medical Oncology and Yale Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-05032-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Immune checkpoint blockade (ICB) only induces tumour response in a subset of non-small cell lung carcinomas (NSCLC). Here the authors do whole genome sequencing and multiplexed quantitative immunofluorescence on patient samples and identify a “dormant” T-cell signature associated with sensitivity to ICB.
