Nature Communications (Jun 2016)
A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells
- Ya Zhang,
- Liang Huang,
- Haiqing Fu,
- Owen K. Smith,
- Chii Mei Lin,
- Koichi Utani,
- Mishal Rao,
- William C. Reinhold,
- Christophe E. Redon,
- Michael Ryan,
- RyangGuk Kim,
- Yang You,
- Harlington Hanna,
- Yves Boisclair,
- Qiaoming Long,
- Mirit I. Aladjem
Affiliations
- Ya Zhang
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Liang Huang
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Haiqing Fu
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Owen K. Smith
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Chii Mei Lin
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Koichi Utani
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Mishal Rao
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- William C. Reinhold
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Christophe E. Redon
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Michael Ryan
- In Silico Solutions
- RyangGuk Kim
- In Silico Solutions
- Yang You
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Harlington Hanna
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Yves Boisclair
- Department of Animal Science, Cornell University
- Qiaoming Long
- Department of Animal Science, Cornell University
- Mirit I. Aladjem
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/ncomms11748
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins.
