Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases

Haibing He; Guangkai Bian; Corey J. Herbst-Gervasoni; Takahiro Mori; Stephen A. Shinsky; Anwei Hou; Xin Mu; Minjian Huang; Shu Cheng; Zixin Deng; David W. Christianson; Ikuro Abe; Tiangang Liu

doi:10.1038/s41467-020-17642-2

Nature Communications (Aug 2020)

Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases

Haibing He,
Guangkai Bian,
Corey J. Herbst-Gervasoni,
Takahiro Mori,
Stephen A. Shinsky,
Anwei Hou,
Xin Mu,
Minjian Huang,
Shu Cheng,
Zixin Deng,
David W. Christianson,
Ikuro Abe,
Tiangang Liu

Affiliations

Haibing He: Graduate School of Pharmaceutical Sciences, University of Tokyo
Guangkai Bian: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University
Corey J. Herbst-Gervasoni: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania
Takahiro Mori: Graduate School of Pharmaceutical Sciences, University of Tokyo
Stephen A. Shinsky: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania
Anwei Hou: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University
Xin Mu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University
Minjian Huang: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University
Shu Cheng: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University
Zixin Deng: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University
David W. Christianson: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania
Ikuro Abe: Graduate School of Pharmaceutical Sciences, University of Tokyo
Tiangang Liu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University

DOI: https://doi.org/10.1038/s41467-020-17642-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Terpene cyclases catalyze the formation of diverse hydrocarbon scaffolds found in terpenoids. Here, the authors report the cryptic function of class I terpene cyclases as aromatic prenyltransferases and the universality of this cryptic feature is confirmed using enzymes from different sources.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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