Correlation between TyG index and non-proliferative retinopathy in type 2 diabetes mellitus

Abstract

Objective To explore the associations of triglyceride-glucose（TyG） index with the degree of non-proliferative diabetic retinopathy（NPDR） in patients with type 2 diabetes mellitus（T2DM）. Methods The clinical data and laboratory results of 235 T2DM patients treated in the First Affiliated Hospital of Xi‘an Medical University from January 2018 to June 2022 were retrospectively analyzed. According to the fundus conditions, the patients were divided into without diabetic retinopathy(DR) group(NDR group, n=75), stage Ⅰ DR group（n=77）, stage Ⅱ DR group（n=59） and stage Ⅲ DR group（n=24）. TyG indexes were calculated and compared among the groups to analyze the risk factors affecting NPDR and the predictive value of TyG index to NPDR. Results There were statistical differences in TyG index between DR groups and NDR group（P<0.05）. Logistic regression analysis showed that course of T2DM, systolic blood pressure, serum creatinine（Scr）, triglyceride（TG） and fasting plasma glucose（FPG） were the risk factors of NPDR. ROC curve showed that the AUC of TyG index for NPDR was significantly larger than that of TG［0.705(0.639-0.771) vs 0.656(0.585-0.726), Z=2.657, P=0.008］. Conclusion TyG index can comprehensively reflect the status of NPDR and is superior to TG in predicting it, which may be used as a biological index to predict the occurrence of NPDR.

Keywords

• type 2 diabetes mellitus
• diabetic retinopathy
• non-proliferative
• degree of retinopathy
• triglyceride-glucose index