Communications Biology (Nov 2021)
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
- Suhasini Joshi,
- Erica DaGama Gomes,
- Tai Wang,
- Adriana Corben,
- Tony Taldone,
- Srinivasa Gandu,
- Chao Xu,
- Sahil Sharma,
- Salma Buddaseth,
- Pengrong Yan,
- Lon Yin L. Chan,
- Askan Gokce,
- Vinagolu K. Rajasekhar,
- Lisa Shrestha,
- Palak Panchal,
- Justina Almodovar,
- Chander S. Digwal,
- Anna Rodina,
- Swathi Merugu,
- NagaVaraKishore Pillarsetty,
- Vlad Miclea,
- Radu I. Peter,
- Wanyan Wang,
- Stephen D. Ginsberg,
- Laura Tang,
- Marissa Mattar,
- Elisa de Stanchina,
- Kenneth H. Yu,
- Maeve Lowery,
- Olivera Grbovic-Huezo,
- Eileen M. O’Reilly,
- Yelena Janjigian,
- John H. Healey,
- William R. Jarnagin,
- Peter J. Allen,
- Chris Sander,
- Hediye Erdjument-Bromage,
- Thomas A. Neubert,
- Steven D. Leach,
- Gabriela Chiosis
Affiliations
- Suhasini Joshi
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Erica DaGama Gomes
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Tai Wang
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Adriana Corben
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Tony Taldone
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Srinivasa Gandu
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Chao Xu
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Sahil Sharma
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Salma Buddaseth
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Pengrong Yan
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Lon Yin L. Chan
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Askan Gokce
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Vinagolu K. Rajasekhar
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Lisa Shrestha
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Palak Panchal
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Justina Almodovar
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Chander S. Digwal
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Anna Rodina
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Swathi Merugu
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- NagaVaraKishore Pillarsetty
- Department of Radiology, Memorial Sloan Kettering Cancer Center
- Vlad Miclea
- Faculty of Automation and Computer Science, Technical University of Cluj-Napoca
- Radu I. Peter
- Faculty of Automation and Computer Science, Technical University of Cluj-Napoca
- Wanyan Wang
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- Stephen D. Ginsberg
- Center for Dementia Research, Nathan Kline Institute
- Laura Tang
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Marissa Mattar
- Antitumour Assessment Core Facility, Memorial Sloan Kettering Cancer Center
- Elisa de Stanchina
- Antitumour Assessment Core Facility, Memorial Sloan Kettering Cancer Center
- Kenneth H. Yu
- David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
- Maeve Lowery
- David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
- Olivera Grbovic-Huezo
- David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
- Eileen M. O’Reilly
- David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
- Yelena Janjigian
- Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College
- John H. Healey
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- William R. Jarnagin
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Peter J. Allen
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Chris Sander
- Department of Data Science, Dana-Farber Cancer Institute
- Hediye Erdjument-Bromage
- Department of Cell Biology, New York University Grossman School of Medicine
- Thomas A. Neubert
- Department of Cell Biology, New York University Grossman School of Medicine
- Steven D. Leach
- David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
- Gabriela Chiosis
- Chemical Biology Program, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s42003-021-02842-3
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 20
Abstract
Joshi, Gomes et al. employ a chemical modulation approach of the cellular interactome to a hyperconnectivity state and show association with the increased response of pancreatic cancer cell lines to specific drugs, including those that target the MAPK-pathways and PI3K-mTOR pathway. To achieve this, the authors employ chemical modulation of the interactome via epichaperome inhibition with the small molecule PU-H71.
