Water transport through rat colonic epithelium during ceftriaxone therapy

Abstract

The dose and time-depended effect of the antibiotic ceftriaxone on net water transport in rat colonic epithelium was studied by colonic loop perfusion technique in situ. Ceftriaxone in dose 50 mg / kg / day caused diarrhea in 10% of rats, in dose 300 mg/kg/day – 25% of rats. Ceftriaxone in both doses decreased net water absorption in rat colon. The resulting effect was more pronounced after 14-days course compared with 5-days.

Keywords

• colon, ceftriaxone, diarrhea