Non-gestational choriocarcinoma of ovary: Clinico-morphological features and diagnostic value of DNA polymorphism study

Abstract

It is generally accepted that choriocarcinoma is a trophoblastic tumor of gestational origin during the reproductive period, but this neoplasm can rarely occur after menopause or be non-gestational making diagnosis a real challenge. In addition to this, somatic neoplasms can also undergo trophoblastic differentiation. The last two types of tumors are most often especially aggressive and have a poor prognosis, so they require more aggressive treatment respectively. To distinguish gestational/non-gestational origin that has an important impact on patient’s management, DNA polymorphism study could be provided.We report a clinical case involving a 58-year-old woman with a history of ovarian non-gestational choriocarcinoma, composed of bulky mass with multiple metastasis including contralateral ovary, omentum, peritoneum, pleura, and colon. The microscopic, immunohistochemical, and molecular features are described, including short tandem repeat (STR) genotype via DNA analysis.

Keywords

• Non-gestational choriocarcinoma
• Choriocarcinomatous differentiation
• DNA polymorphism study