Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides

Xu Bao; Qian Wang; Jieping Zhu

doi:10.1038/s41467-019-08741-w

Nature Communications (Feb 2019)

Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides

Xu Bao,
Qian Wang,
Jieping Zhu

Affiliations

Xu Bao: Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH5304
Qian Wang: Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH5304
Jieping Zhu: Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH5304

DOI: https://doi.org/10.1038/s41467-019-08741-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 7

Abstract

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Functionalization of carbon radicals formed via 1,5-hydrogen atom transfer of amidyl radicals is an underdeveloped protocol for remote C–H functionalization. Here, the authors report a Cu-catalyzed γ-azidation and oxidative δ-trifluoromethylation of benzohydrazides for the synthesis of more functionalized amides.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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