UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells

Juan Dong; Xiaoli Wang; Congcong Cao; Yujiao Wen; Akihiko Sakashita; Si Chen; Jin Zhang; Yue Zhang; Liquan Zhou; Mengcheng Luo; Mingxi Liu; Aihua Liao; Satoshi H. Namekawa; Shuiqiao Yuan

doi:10.1038/s41467-019-12455-4

Nature Communications (Oct 2019)

UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells

Juan Dong,
Xiaoli Wang,
Congcong Cao,
Yujiao Wen,
Akihiko Sakashita,
Si Chen,
Jin Zhang,
Yue Zhang,
Liquan Zhou,
Mengcheng Luo,
Mingxi Liu,
Aihua Liao,
Satoshi H. Namekawa,
Shuiqiao Yuan

Affiliations

Juan Dong: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Xiaoli Wang: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Congcong Cao: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Yujiao Wen: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Akihiko Sakashita: Division of Reproductive Sciences, Cincinnati Children’s Hospital Medical Center
Si Chen: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Jin Zhang: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Yue Zhang: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Liquan Zhou: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Mengcheng Luo: Department of Tissue and Embryology, School of Basic Medical Sciences, Wuhan University
Mingxi Liu: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Aihua Liao: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Satoshi H. Namekawa: Division of Reproductive Sciences, Cincinnati Children’s Hospital Medical Center
Shuiqiao Yuan: Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-019-12455-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Retrotransposons are silenced by an epigenetic mechanism and piRNA pathway in the mammalian germline. Here, the authors report that UHRF1 suppresses retrotransposons by interacting with PRMT5 and PIWI proteins during spermatogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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