Communications Biology (Feb 2021)
Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation
- Travis T. Sims,
- Molly B. El Alam,
- Tatiana V. Karpinets,
- Stephanie Dorta-Estremera,
- Venkatesh L. Hegde,
- Sita Nookala,
- Kyoko Yoshida-Court,
- Xiaogang Wu,
- Greyson W. G. Biegert,
- Andrea Y. Delgado Medrano,
- Travis Solley,
- Mustapha Ahmed-Kaddar,
- Bhavana V. Chapman,
- K. Jagannadha Sastry,
- Melissa P. Mezzari,
- Joseph F. Petrosino,
- Lilie L. Lin,
- Lois Ramondetta,
- Anuja Jhingran,
- Kathleen M. Schmeler,
- Nadim J. Ajami,
- Jennifer Wargo,
- Lauren E. Colbert,
- Ann H. Klopp
Affiliations
- Travis T. Sims
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Molly B. El Alam
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Tatiana V. Karpinets
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Stephanie Dorta-Estremera
- Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center and the UTHealth Graduate School of Biomedical Sciences at Houston
- Venkatesh L. Hegde
- Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center and the UTHealth Graduate School of Biomedical Sciences at Houston
- Sita Nookala
- Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center and the UTHealth Graduate School of Biomedical Sciences at Houston
- Kyoko Yoshida-Court
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xiaogang Wu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Greyson W. G. Biegert
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Andrea Y. Delgado Medrano
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Travis Solley
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Mustapha Ahmed-Kaddar
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Bhavana V. Chapman
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- K. Jagannadha Sastry
- Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center and the UTHealth Graduate School of Biomedical Sciences at Houston
- Melissa P. Mezzari
- Department of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine
- Joseph F. Petrosino
- Department of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine
- Lilie L. Lin
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Lois Ramondetta
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Anuja Jhingran
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Kathleen M. Schmeler
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Nadim J. Ajami
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Jennifer Wargo
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Lauren E. Colbert
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Ann H. Klopp
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s42003-021-01741-x
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 10
Abstract
Travis Sims and Molly El Alam et al. show that diversity of gut microbiota is associated with a favorable response to chemoradiation for cervical cancer and use flow cytometry to show that patients with high microbiome diversity had increased tumor infiltration of CD4+ lymphocytes as well as activated subsets of CD4 cells expressing ki67+ and CD69+ throughout radiation therapy. These results reveal how modulation of the gut microbiota could potentially be used to improve treatment efficacy and outcome.
