Терапевтический архив (Sep 2016)

Lipoprotein(a), its autoantibodies, and circulating T lymphocyte subpopulations as independent risk factors for coronary artery atherosclerosis

  • O I Afanasievа,
  • E A Pylaeva,
  • E A Klesareva,
  • A V Potekhina,
  • S I Provatorov,
  • M I Afanasieva,
  • T L Krasnikova,
  • V P Masenko,
  • T I Arefieva,
  • S N Pokrovsky

DOI
https://doi.org/10.17116/terarkh201688931-38
Journal volume & issue
Vol. 88, no. 9
pp. 31 – 38

Abstract

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Aim. To study the role of lipoprotein(a) [Lp(a)] as a potential autoantigen causing the activation of immunocompetent cells in atherosclerosis. Subjects and methods. A total of 104 men with stable coronary artery (CA) disease and different degrees of progressive coronary atherosclerosis were examined. Clinical blood analysis was carried out and lymphocyte subpopulations (CD4+, Th1, Th17, and Treg) were determined using immunofluorescence and flow cytometry. In addition, the indicators of blood lipid composition, Lp(a), autoantibody (autoAb) titer to Lp(a), and low-density lipoproteins (LDL), and the lymphocyte activation marker sCD25 were also measured. Results. The Lp(a) level was shown to predict the severity of CA lesions (β=0.28, p

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