Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1

Abstract

Commensal bacteria, the vast majority of which reside in the gut, are involved in development of many diseases, including atherosclerotic vascular disease. Here the authors show that these bacteria remotely increase expression of vascular microRNA-204, which targets Sirt1 in the endothelium to impair endothelial function.