Nature Communications (Jun 2021)
Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia
- Urs Braun,
- Anais Harneit,
- Giulio Pergola,
- Tommaso Menara,
- Axel Schäfer,
- Richard F. Betzel,
- Zhenxiang Zang,
- Janina I. Schweiger,
- Xiaolong Zhang,
- Kristina Schwarz,
- Junfang Chen,
- Giuseppe Blasi,
- Alessandro Bertolino,
- Daniel Durstewitz,
- Fabio Pasqualetti,
- Emanuel Schwarz,
- Andreas Meyer-Lindenberg,
- Danielle S. Bassett,
- Heike Tost
Affiliations
- Urs Braun
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Anais Harneit
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Giulio Pergola
- Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro
- Tommaso Menara
- Mechanical Engineering Department, University of California at Riverside
- Axel Schäfer
- Bender Institute of Neuroimaging, Justus Liebig University Giessen
- Richard F. Betzel
- Department of Psychological and Brain Sciences, Indiana University
- Zhenxiang Zang
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Janina I. Schweiger
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Xiaolong Zhang
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Kristina Schwarz
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Junfang Chen
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Giuseppe Blasi
- Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro
- Alessandro Bertolino
- Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro
- Daniel Durstewitz
- Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Fabio Pasqualetti
- Mechanical Engineering Department, University of California at Riverside
- Emanuel Schwarz
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Andreas Meyer-Lindenberg
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Danielle S. Bassett
- Department of Bioengineering, University of Pennsylvania
- Heike Tost
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- DOI
- https://doi.org/10.1038/s41467-021-23694-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Working memory requires the brain to switch between cognitive states and activity patterns. Here, the authors show that the steering of these neural network dynamics is influenced by dopamine D1- and D2-receptor function and altered in schizophrenia.
