6mer seed toxicity in tumor suppressive microRNAs

Quan Q. Gao; William E. Putzbach; Andrea E. Murmann; Siquan Chen; Aishe A. Sarshad; Johannes M. Peter; Elizabeth T. Bartom; Markus Hafner; Marcus E. Peter

doi:10.1038/s41467-018-06526-1

Nature Communications (Oct 2018)

6mer seed toxicity in tumor suppressive microRNAs

Quan Q. Gao,
William E. Putzbach,
Andrea E. Murmann,
Siquan Chen,
Aishe A. Sarshad,
Johannes M. Peter,
Elizabeth T. Bartom,
Markus Hafner,
Marcus E. Peter

Affiliations

Quan Q. Gao: Department of Medicine, Division Hematology/Oncology, Northwestern University
William E. Putzbach: Department of Medicine, Division Hematology/Oncology, Northwestern University
Andrea E. Murmann: Department of Medicine, Division Hematology/Oncology, Northwestern University
Siquan Chen: Cellular Screening Center, Institute for Genomics & Systems Biology, The University of Chicago
Aishe A. Sarshad: Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH
Johannes M. Peter: DigiPen Institute of Technology
Elizabeth T. Bartom: Department of Biochemistry and Molecular Genetics, Northwestern University
Markus Hafner: Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH
Marcus E. Peter: Department of Medicine, Division Hematology/Oncology, Northwestern University

DOI: https://doi.org/10.1038/s41467-018-06526-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequences.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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