Sanhuang decoction in improving Qi deficiency of patients with triple negative breast cancer

Abstract

Objective To observe the effect of Sanhuang decoction on the symptoms of Qi deficiency and quality of life in patients with triple negative breast cancer (TNBC) and explore its mechanism. Methods From January to December 2018, 30 patients with TNBC in the Breast Surgery of Jiangsu Provincial Hospital of Chinese Medicine were randomly divided into treatment group (n=15) and control group (n=15). The patients in treatment group received Sanhuang decoction on the basis of basic treatment, with two courses of treatment （3 months was a course）. The patient's symptoms of Qi deficiency, immune indicators (CD3+, CD4+, CD8+, CD4+/CD8+, IL-2, IFN-γ) levels before treatment and 3 and 6 months after treatment, and safety indicators were compared. Results After 6 months of treatment, the symptoms of breath shortness, fatigued spirit, lack of strength, spontaneous sweating, and lazy speech in the treatment group were improved, and the levels of immune indicators IL-2 and IFN-γ were improved, and there were statistically significant differences compared to the control group (P＜0.05). Although there were improvements in CD3+, CD4+, CD8+, and CD4+/CD8+, but with no statistically significant difference compared to the control group (P＞0.05). Both groups of patients showed no adverse reactions before and after treatment. Conclusion Sanhuang decoction can significantly improve the symptoms of Qi deficiency of patients with TNBC. The mechanism may be related to the improvement of immune level of patients with Sanhuang decoction.

Keywords

• sanhuang decoction
• breast cancer
• triple-negative
• qi deficiency
• immune function