Toxic reactions of non-steroidal anti-inflammatory drugs in the Russian Federation, analysis of the national database “Pharmacovigilance”

Abstract

Non-steroidal anti-inflammatory drugs are widely used by patients and medical workers, both in the Russian Federation and abroad. Despite the well-established public opinion about the safety of this group of drugs, their use is associated with toxic reactions. This study analyzed the download of the national database “Pharmacovigilance” for 11 years (for the period 2010 to 2020) with the identification of the main representatives of this class of drugs that cause adverse reactions. To compare several independent samples of patients who received different groups of NSAIDs, Kruskel-Wallis ANOVA rank analysis of variations was used using Microsoft Excel 2013, STATISTICA 10.0 packages. Based on the results obtained, it can be concluded that the main proportion of adverse drug reactions (ADR) is associated with the female sex and the use of metamizole sodium. In addition, fatal AEs have been reported, most of which are associated with the use of paracetamol.

Keywords

• фармаконадзор
• нестероидные противовоспалительные средства
• нежелательные реакции
• аис рзн
• лекарственное поражение печени