Cocaine’s cerebrovascular vasoconstriction is associated with astrocytic Ca2+ increase in mice

Yanzuo Liu; Yueming Hua; Kicheon Park; Nora D. Volkow; Yingtian Pan; Congwu Du

doi:10.1038/s42003-022-03877-w

Communications Biology (Sep 2022)

Cocaine’s cerebrovascular vasoconstriction is associated with astrocytic Ca2+ increase in mice

Yanzuo Liu,
Yueming Hua,
Kicheon Park,
Nora D. Volkow,
Yingtian Pan,
Congwu Du

Affiliations

Yanzuo Liu: Department of Biomedical Engineering, Stony Brook University
Yueming Hua: Department of Biomedical Engineering, Stony Brook University
Kicheon Park: Department of Biomedical Engineering, Stony Brook University
Nora D. Volkow: National Institute on Drug Abuse
Yingtian Pan: Department of Biomedical Engineering, Stony Brook University
Congwu Du: Department of Biomedical Engineering, Stony Brook University

DOI: https://doi.org/10.1038/s42003-022-03877-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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Multimodal imaging of the mouse brain following acute cocaine application revealed that cocaine caused a biphasic calcium response in neurons, but not astrocytes, suggesting that these cells play different roles in mediating neurovascular coupling to cocaine.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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