Endocrinology, Diabetes & Metabolism Case Reports (Apr 2019)

Anterior hypopituitarism secondary to biopsy-proven IgG4-related hypophysitis in a young man

  • H Joshi,
  • M Hikmat,
  • A P Devadass,
  • S O Oyibo,
  • S V Sagi

DOI
https://doi.org/10.1530/EDM-18-0137
Journal volume & issue
Vol. 1, no. 1
pp. 1 – 5

Abstract

Read online

IgG4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory condition which can affect various organs including the pituitary gland. The true annual incidence of this condition remains widely unknown. In addition, it is unclear whether IgG4 antibodies are causative or the end result of a trigger. With no specific biomarkers available, the diagnosis of IgG4-related hypophysitis remains a challenge. Additionally, there is a wide differential diagnosis. We report a case of biopsy-proven IgG4-related hypophysitis in a young man with type 2 diabetes mellitus.