Leukemia Research Reports (Jan 2022)

A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement

  • Labrini Papanastasiou,
  • Nikitas Skarakis,
  • Maria Vardaka,
  • Anastasia Dimitriadi,
  • Pinelopi Lampropoulou,
  • Anastasia Perpinia,
  • Eleftherios Vidalakis,
  • Theodosia Choreftaki,
  • Theodoros Marinakis,
  • Theodora Kounadi,
  • Ioannis-Anastasios Vatalas,
  • Eurydiki Michalis

Journal volume & issue
Vol. 17
p. 100318

Abstract

Read online

We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium wall. An adrenal biopsy revealed the presence of a DLBCL, with triple expression of bcl2, bcl6, C-MYC(+70%). Following six cycles of systemic immunochemotherapy with R-DA-EPOCH, and high methotrexate dose for CNS prophylaxis a marked decrease of lymphoma infiltration was observed. The selection of the appropriate treatment modality can lead to profound response and improve patient's outcome.

Keywords