The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway

Mona Singh; Santosh Kumar; Baldeep Singh; Preeti Jain; Anjna Kumari; Isha Pahuja; Shivam Chaturvedi; Durbaka Vijay Raghava Prasad; Ved Prakash Dwivedi; Gobardhan Das

doi:10.1038/s42003-022-03693-2

Communications Biology (Jul 2022)

The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway

Mona Singh,
Santosh Kumar,
Baldeep Singh,
Preeti Jain,
Anjna Kumari,
Isha Pahuja,
Shivam Chaturvedi,
Durbaka Vijay Raghava Prasad,
Ved Prakash Dwivedi,
Gobardhan Das

Affiliations

Mona Singh: Special Centre for Molecular Medicine, Jawaharlal Nehru University
Santosh Kumar: Immunobiology Group, International Centre for Genetic Engineering and Biotechnology
Baldeep Singh: Special Centre for Molecular Medicine, Jawaharlal Nehru University
Preeti Jain: Special Centre for Molecular Medicine, Jawaharlal Nehru University
Anjna Kumari: Immunobiology Group, International Centre for Genetic Engineering and Biotechnology
Isha Pahuja: Immunobiology Group, International Centre for Genetic Engineering and Biotechnology
Shivam Chaturvedi: Immunobiology Group, International Centre for Genetic Engineering and Biotechnology
Durbaka Vijay Raghava Prasad: Department of Microbiology, Yogi Vemana University
Ved Prakash Dwivedi: Immunobiology Group, International Centre for Genetic Engineering and Biotechnology
Gobardhan Das: Special Centre for Molecular Medicine, Jawaharlal Nehru University

DOI: https://doi.org/10.1038/s42003-022-03693-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

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The adamantine derivative SQ109 induces protective pro-inflammatory cytokines and promotes Th1 and Th17-immune responses that inhibit bacterial burden in a tuberculosis mouse model.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal