Activation of Xist by an evolutionarily conserved function of KDM5C demethylase

Milan Kumar Samanta; Srimonta Gayen; Clair Harris; Emily Maclary; Yumie Murata-Nakamura; Rebecca M. Malcore; Robert S. Porter; Patricia M. Garay; Christina N. Vallianatos; Paul B. Samollow; Shigeki Iwase; Sundeep Kalantry

doi:10.1038/s41467-022-30352-1

Nature Communications (May 2022)

Activation of Xist by an evolutionarily conserved function of KDM5C demethylase

Milan Kumar Samanta,
Srimonta Gayen,
Clair Harris,
Emily Maclary,
Yumie Murata-Nakamura,
Rebecca M. Malcore,
Robert S. Porter,
Patricia M. Garay,
Christina N. Vallianatos,
Paul B. Samollow,
Shigeki Iwase,
Sundeep Kalantry

Affiliations

Milan Kumar Samanta: Department of Human Genetics, University of Michigan Medical School
Srimonta Gayen: Department of Human Genetics, University of Michigan Medical School
Clair Harris: Department of Human Genetics, University of Michigan Medical School
Emily Maclary: Department of Human Genetics, University of Michigan Medical School
Yumie Murata-Nakamura: Department of Human Genetics, University of Michigan Medical School
Rebecca M. Malcore: Department of Human Genetics, University of Michigan Medical School
Robert S. Porter: Department of Human Genetics, University of Michigan Medical School
Patricia M. Garay: Department of Human Genetics, University of Michigan Medical School
Christina N. Vallianatos: Department of Human Genetics, University of Michigan Medical School
Paul B. Samollow: Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University
Shigeki Iwase: Department of Human Genetics, University of Michigan Medical School
Sundeep Kalantry: Department of Human Genetics, University of Michigan Medical School

DOI: https://doi.org/10.1038/s41467-022-30352-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Here the authors show eutherian mammals co-opted the histone demethylase KDM5C during sex-chromosome evolution to induce X-chromosome inactivation by upregulating Xist expression selectively in females.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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