Nature Communications (Feb 2018)
Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
- Xiao Wang,
- Fengfeng Li,
- Liang Xie,
- Janet Crane,
- Gehua Zhen,
- Yuji Mishina,
- Ruoxian Deng,
- Bo Gao,
- Hao Chen,
- Shen Liu,
- Ping Yang,
- Manman Gao,
- Manli Tu,
- Yiguo Wang,
- Mei Wan,
- Cunyi Fan,
- Xu Cao
Affiliations
- Xiao Wang
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Fengfeng Li
- Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital
- Liang Xie
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Janet Crane
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Gehua Zhen
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Yuji Mishina
- School of Dentistry, University of Michigan
- Ruoxian Deng
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Bo Gao
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Hao Chen
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Shen Liu
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Ping Yang
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Manman Gao
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Manli Tu
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Yiguo Wang
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Mei Wan
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- Cunyi Fan
- Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital
- Xu Cao
- Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
- DOI
- https://doi.org/10.1038/s41467-018-02988-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Heterotopic ossification (HO) is a painful disease of unknown etiology characterized by extraskeletal bone formation after injury. Here the authors show that TGF-β is increased in HO lesions, where it promotes the early stages of HO pathology, and demonstrate that TGF-β inhibition ameliorates HO in mice.
