Nature Communications (Jun 2019)

Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption

  • Jesús E. Villanueva,
  • Christopher Livelo,
  • Adriana S. Trujillo,
  • Sahaana Chandran,
  • Brendon Woodworth,
  • Leo Andrade,
  • Hiep D. Le,
  • Uri Manor,
  • Satchidananda Panda,
  • Girish C. Melkani

DOI
https://doi.org/10.1038/s41467-019-10563-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Time-restricted feeding (TRF) has beneficial metabolic effects. Here the authors examine how TRF impacts muscle physiology using fly models of metabolically adverse conditions, including diet and genetic models of obesity as well as circadian rhythm disruption, and find that TRF ameliorates skeletal muscle dysfunction.