Activity of 2-benzyl-1-(2-hydroxyethyl)-5-nitroindazolin-3-one on Trypanosoma cruzi Bloodstream Trypomastigotes (Y strain): In Vitro and In Vivo Studies

Cristina Fonseca-Berzal; Cristiane França da Silva; Marcos Meuser Batista; Francisca Hildemagna Guedes-da-Silva; Mariane Vasconcelos; Kelly C. Demarque; José A. Escario; Vicente J. Arán; Maria de Nazaré C. Soeiro; Alicia Gómez-Barrio

doi:10.3390/proceedings1060655

Proceedings (Oct 2017)

Activity of 2-benzyl-1-(2-hydroxyethyl)-5-nitroindazolin-3-one on Trypanosoma cruzi Bloodstream Trypomastigotes (Y strain): In Vitro and In Vivo Studies

Cristina Fonseca-Berzal,
Cristiane França da Silva,
Marcos Meuser Batista,
Francisca Hildemagna Guedes-da-Silva,
Mariane Vasconcelos,
Kelly C. Demarque,
José A. Escario,
Vicente J. Arán,
Maria de Nazaré C. Soeiro,
Alicia Gómez-Barrio

Affiliations

Cristina Fonseca-Berzal: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid (CEI Campus Moncloa UCM-UPM and CSIC), Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
Cristiane França da Silva: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, Brazil
Marcos Meuser Batista: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, Brazil
Francisca Hildemagna Guedes-da-Silva: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, Brazil
Mariane Vasconcelos: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, Brazil
Kelly C. Demarque: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, Brazil
José A. Escario: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid (CEI Campus Moncloa UCM-UPM and CSIC), Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
Vicente J. Arán: Instituto de Química Médica (IQM), CSIC, Calle Juan de la Cierva 3, 28006 Madrid, Spain
Maria de Nazaré C. Soeiro: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, Brazil
Alicia Gómez-Barrio: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid (CEI Campus Moncloa UCM-UPM and CSIC), Pza. Ramón y Cajal s/n, 28040 Madrid, Spain

DOI: https://doi.org/10.3390/proceedings1060655
Journal volume & issue: Vol. 1, no. 6
p. 655

Abstract

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Benznidazole and nifurtimox, the currently available drugs for the specific treatment of Chagas disease, show limited effectiveness and high toxicity that prompt the identification of therapeutic alternatives. [...]

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Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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