Molecules (Jul 2014)

Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer

  • Meena S. Thakur,
  • Archana Khurana,
  • Mitchell Kronenberg,
  • Amy R. Howell

DOI
https://doi.org/10.3390/molecules190710090
Journal volume & issue
Vol. 19, no. 7
pp. 10090 – 10102

Abstract

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Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2ꞌꞌ-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.

Keywords