Diethyl(benzamido(diisopropoxyphosphoryl)methyl) phosphonate

Abstract

Bisphosphonates are widely used in medicine and related areas, mainly for the treatment of bone diseases, such as osteoporosis. However, their synthesis is usually performed under harsh reaction conditions. In order to overcome this limitation, the present work illustrates a new synthetic route to access the title α-aminobisphosphonate in milder reaction conditions using α-phosphorylated imines as key intermediates.

Keywords

• bisphosphonates
• α-iminophosphonates
• Pudovik reaction