NMR Data Analysis of Manidipine Hydrochloride

Abstract

Manidipine hydrochloride is the third generation of new synthetic antihypertensive drugs. The structure of manidipine hydrochloride was confirmed with 1D and 2D nuclear magnetic resonance (NMR) techniques, such as 1H NMR, 13C NMR, DEPT-135, 1H-1H COSY, 1H-1H NOESY, 1H-13C HSQC, and 1H-13C HMBC. Some abnormal signals in 1H NMR and 13C NMR spectra were further discussed.

Keywords

• liquid-state nmr
• structural elucidation
• 2d nmr
• manidipine hydrochloride
• quadrupolar relaxation of 14n nucleus