The Efficacy of Combination Regime in Helicobacter Pylori Eradication: A Cross-Sectional Study from an Experienced Endoscopy Center

Abstract

Aim:The success of antibiotics used for eradication in the treatment of Helicobacter pylori (Hp)-positive gastritis is controversial. This study aims to evaluate the post-treatment eradication success/failure of Hp-positive gastritis cases, discuss antibiotic resistance, and what we can do additionally.Methods:The data of 1,471 patients who underwent upper gastrointestinal endoscopy between January 1 and December 31, 2019, were retrospectively evaluated through the hospital digital recording system. Of these, data of 126 patients who have been diagnosed with HP-positive gastritis and treated with a trio of clarithromycin, amoxicillin, and omeprazole were analyzed. Initial and control endoscopic pathologies and Hp-positivity were compared.Results:In the control of 126 patients, 87 (69%) patients had a normal endoscopic appearance, but only 46 (36.5%) patients were normal in the histopathological examinations of biopsies. Regardless of the severity, complete eradication of Hp was possible in 31 (24.6%) patients. There was no statistically significant difference in Hp detection rates after treatment (p=0.719 for 1+, p=0.583 for 2+, p for 3+)=0.980).Conclusion:In gastritis cases, Hp positivity continues despite the treatment, although the pathological severity changes. It is appropriate to discuss the effectiveness of routine treatments and to take culture/antibiogram, even bismuth including preparations to the forefront.

Keywords

• helicobacter pylori
• gastritis
• antibiogram