Nature Communications (Sep 2021)
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion
- Shintaro Okumura,
- Yusuke Konishi,
- Megumi Narukawa,
- Yuki Sugiura,
- Shin Yoshimoto,
- Yuriko Arai,
- Shintaro Sato,
- Yasuo Yoshida,
- Shunya Tsuji,
- Ken Uemura,
- Masahiro Wakita,
- Tatsuyuki Matsudaira,
- Tomonori Matsumoto,
- Shimpei Kawamoto,
- Akiko Takahashi,
- Yoshiro Itatani,
- Hiroaki Miki,
- Manabu Takamatsu,
- Kazutaka Obama,
- Kengo Takeuchi,
- Makoto Suematsu,
- Naoko Ohtani,
- Yosuke Fukunaga,
- Masashi Ueno,
- Yoshiharu Sakai,
- Satoshi Nagayama,
- Eiji Hara
Affiliations
- Shintaro Okumura
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Yusuke Konishi
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Megumi Narukawa
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Yuki Sugiura
- Keio University School of Medicine
- Shin Yoshimoto
- The Cancer Institute, Japanese Foundation for Cancer Research (JFCR)
- Yuriko Arai
- The Cancer Institute, Japanese Foundation for Cancer Research (JFCR)
- Shintaro Sato
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Yasuo Yoshida
- School of Dentistry, Aichi Gakuin University
- Shunya Tsuji
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Ken Uemura
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Masahiro Wakita
- Immunology Frontier Research Centre (IFReC), Osaka University
- Tatsuyuki Matsudaira
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Tomonori Matsumoto
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Shimpei Kawamoto
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Akiko Takahashi
- The Cancer Institute, Japanese Foundation for Cancer Research (JFCR)
- Yoshiro Itatani
- Graduate School of Medicine, Kyoto University
- Hiroaki Miki
- Research Institute for Microbial Diseases (RIMD), Osaka University
- Manabu Takamatsu
- The Cancer Institute Hospital, JFCR
- Kazutaka Obama
- Graduate School of Medicine, Kyoto University
- Kengo Takeuchi
- The Cancer Institute, Japanese Foundation for Cancer Research (JFCR)
- Makoto Suematsu
- Keio University School of Medicine
- Naoko Ohtani
- Osaka City University Graduate School of Medicine
- Yosuke Fukunaga
- The Cancer Institute Hospital, JFCR
- Masashi Ueno
- The Cancer Institute Hospital, JFCR
- Yoshiharu Sakai
- Graduate School of Medicine, Kyoto University
- Satoshi Nagayama
- The Cancer Institute Hospital, JFCR
- Eiji Hara
- Research Institute for Microbial Diseases (RIMD), Osaka University
- DOI
- https://doi.org/10.1038/s41467-021-25965-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Several bacteria in the gut microbiota have been associated with colorectal cancer (CRC) but it is not completely clear whether they have a role in tumourigenesis. Here, the authors show enrichment of 12 bacterial taxa in two cohorts of CRC patients and that two Porphyromonas species accelerate CRC onset through butyrate secretion.
