Pathogenetic Correction of Metabolic Disturbances in Chronic Liver Affections

Abstract

The available drugs for the treatment of chronic liver affections (the adequate model is chronic hepatitis C) include agents of metabolic therapy, whose efficacy is not always enough, that required the search for original mitochondrial substrates on the basis of succinate. Such agents were composed as a pharmaceutical group named «Substrates of Energetic Metabolism» or «Substrate Antihypoxants». The review presents the description of the pharmacological effects of remaxole and cytoflavin, evident from lower levels of active metabolites of oxygen that increases the clinical efficacy of the therapy. Their role in the metabolic reactions in chronic liver affections is exclusive and rather actual.

Keywords

• chronic liver affections
• metabolic therapy
• cytoflavin
• remaxole
• pharmacological effects
• energetic metabolism substrates