Subnuclear gene positioning through lamina association affects copper tolerance

Yuki Sakamoto; Mayuko Sato; Yoshikatsu Sato; Akihito Harada; Takamasa Suzuki; Chieko Goto; Kentaro Tamura; Kiminori Toyooka; Hiroshi Kimura; Yasuyuki Ohkawa; Ikuko Hara-Nishimura; Shingo Takagi; Sachihiro Matsunaga

doi:10.1038/s41467-020-19621-z

Nature Communications (Nov 2020)

Subnuclear gene positioning through lamina association affects copper tolerance

Yuki Sakamoto,
Mayuko Sato,
Yoshikatsu Sato,
Akihito Harada,
Takamasa Suzuki,
Chieko Goto,
Kentaro Tamura,
Kiminori Toyooka,
Hiroshi Kimura,
Yasuyuki Ohkawa,
Ikuko Hara-Nishimura,
Shingo Takagi,
Sachihiro Matsunaga

Affiliations

Yuki Sakamoto: Imaging Frontier Center, Organization for Research Advancement, Tokyo University of Science
Mayuko Sato: RIKEN Center for Sustainable Resource Science
Yoshikatsu Sato: Institute of Transformative Bio-Molecules, Nagoya University
Akihito Harada: Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
Takamasa Suzuki: College of Bioscience and Biotechnology, Chubu University
Chieko Goto: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kentaro Tamura: School of Food and Nutritional Sciences, University of Shizuoka
Kiminori Toyooka: RIKEN Center for Sustainable Resource Science
Hiroshi Kimura: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Yasuyuki Ohkawa: Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
Ikuko Hara-Nishimura: Faculty of Science and Engineering, Konan University
Shingo Takagi: Department of Biological Sciences, Graduate School of Science, Osaka University
Sachihiro Matsunaga: Imaging Frontier Center, Organization for Research Advancement, Tokyo University of Science

DOI: https://doi.org/10.1038/s41467-020-19621-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

The nuclear lamina regulates chromatin organization and gene positioning. Here the authors show that CROWDED NUCLEI proteins contribute to the meshwork lamina structure in Arabidopsis nuclei and regulate copper tolerance by promoting lamina association and expression of copper response genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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