Mediators of Inflammation (Jan 2023)

Effects of Ferroptosis on Cardiovascular Diseases

  • Jiayi Xu,
  • Jinkui Pi,
  • Yanjing Zhang,
  • Jinhan Zhou,
  • Shuxia Zhang,
  • Sisi Wu

DOI
https://doi.org/10.1155/2023/6653202
Journal volume & issue
Vol. 2023

Abstract

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Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and the buildup of reactive oxygen species on the membrane lipids leads to cell death. An increasing body of evidence suggests that ferroptosis plays a significant role in the development and occurrence of cardiovascular diseases. In this paper, we mainly elaborated on the molecular mechanisms regulating ferroptosis and its impact on cardiovascular disease to lay the groundwork for future studies on the prophylaxis and treatment of this patient population.