Plastic roles of pericytes in the blood–retinal barrier

Do Young Park; Junyeop Lee; Jaeryung Kim; Kangsan Kim; Seonpyo Hong; Sangyeul Han; Yoshiaki Kubota; Hellmut G. Augustin; Lei Ding; Jin Woo Kim; Hail Kim; Yulong He; Ralf H. Adams; Gou Young Koh

doi:10.1038/ncomms15296

Nature Communications (May 2017)

Plastic roles of pericytes in the blood–retinal barrier

Do Young Park,
Junyeop Lee,
Jaeryung Kim,
Kangsan Kim,
Seonpyo Hong,
Sangyeul Han,
Yoshiaki Kubota,
Hellmut G. Augustin,
Lei Ding,
Jin Woo Kim,
Hail Kim,
Yulong He,
Ralf H. Adams,
Gou Young Koh

Affiliations

Do Young Park: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Junyeop Lee: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Jaeryung Kim: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Kangsan Kim: Center for Vascular Research, Institute of Basic Science (IBS)
Seonpyo Hong: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Sangyeul Han: Center for Vascular Research, Institute of Basic Science (IBS)
Yoshiaki Kubota: The Laboratory of Vascular Biology, Keio University
Hellmut G. Augustin: Division of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH Alliance
Lei Ding: Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia Stem Cell Initiative, Columbia University Medical Center
Jin Woo Kim: Department of Biological Sciences, KAIST
Hail Kim: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Yulong He: Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University
Ralf H. Adams: Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster
Gou Young Koh: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/ncomms15296
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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