Nature Communications (May 2017)
ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics
- Yanlei Ma,
- Jiping Yue,
- Yao Zhang,
- Chenzhang Shi,
- Matt Odenwald,
- Wenguang G. Liang,
- Qing Wei,
- Ajay Goel,
- Xuewen Gou,
- Jamie Zhang,
- Shao-Yu Chen,
- Wei-Jen Tang,
- Jerrold R. Turner,
- Feng Yang,
- Hong Liang,
- Huanlong Qin,
- Xiaoyang Wu
Affiliations
- Yanlei Ma
- Department of GI surgery, Shanghai Tenth People’s Hospital Affiliated with Tongji University
- Jiping Yue
- Ben May Department for Cancer Research, The University of Chicago
- Yao Zhang
- Department of Colorectal Surgery, Fudan University Shanghai Cancer Center
- Chenzhang Shi
- Department of GI surgery, Shanghai Tenth People’s Hospital Affiliated with Tongji University
- Matt Odenwald
- Pritzker School of Medicine, University of Chicago
- Wenguang G. Liang
- Ben May Department for Cancer Research, The University of Chicago
- Qing Wei
- Department of Pathology, Shanghai Tenth People’s Hospital Affiliated with Tongji University
- Ajay Goel
- Center for Gastrointestinal Research, Center for Epigenetics, Cancer Prevention and Cancer Genomics, Baylor Scott & White Research Institute and Charles A. Sammons Cancer Center
- Xuewen Gou
- Ben May Department for Cancer Research, The University of Chicago
- Jamie Zhang
- Ben May Department for Cancer Research, The University of Chicago
- Shao-Yu Chen
- Department of Pharmacology and Toxicology, University of Louisville Health Science Center
- Wei-Jen Tang
- Ben May Department for Cancer Research, The University of Chicago
- Jerrold R. Turner
- Departments of Pathology and Medicine (GI), Brigham and Women’s Hospital, Harvard Medical School
- Feng Yang
- State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China, Guanxi Normal University
- Hong Liang
- State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China, Guanxi Normal University
- Huanlong Qin
- Department of GI surgery, Shanghai Tenth People’s Hospital Affiliated with Tongji University
- Xiaoyang Wu
- Ben May Department for Cancer Research, The University of Chicago
- DOI
- https://doi.org/10.1038/ncomms15375
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
The cytoskeleton plays a key role in cell/cell junction formation, but how the coordinated behaviour of the cytoskeleton contributes is not known. Here the authors show that actin-microtubule crosslinker ACF7 plays a key role in tight junction stabilization and wound healing in intestinal epithelium.
