Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex

Xuejuan Wang; Salar Ahmad; Zhihui Zhang; Jacques Côté; Gang Cai

doi:10.1038/s41467-018-03504-5

Nature Communications (Mar 2018)

Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex

Xuejuan Wang,
Salar Ahmad,
Zhihui Zhang,
Jacques Côté,
Gang Cai

Affiliations

Xuejuan Wang: Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science & Technology of China
Salar Ahmad: St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, CHU de Québec Research Center-Oncology Axis
Zhihui Zhang: Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science & Technology of China
Jacques Côté: St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, CHU de Québec Research Center-Oncology Axis
Gang Cai: Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science & Technology of China

DOI: https://doi.org/10.1038/s41467-018-03504-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The NuA4 histone acetyltransferase complex is important for gene regulation, DNA repair processes and cell cycle progression. Here the authors give molecular insights into the NuA4 complex by presenting the cryo-EM structures of the NuA4 TEEAA (Tra1, Eaf1, Eaf5, actin, and Arp4) and TEEAA-piccolo NuA4 assemblies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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