Nature Communications (Sep 2022)
Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis
- Nutan Chaudhari,
- Alison D. Findlay,
- Andrew W. Stevenson,
- Tristan D. Clemons,
- Yimin Yao,
- Amar Joshi,
- Sepidar Sayar,
- Gordon Wallace,
- Suzanne Rea,
- Priyanka Toshniwal,
- Zhenjun Deng,
- Philip E. Melton,
- Nicole Hortin,
- K. Swaminathan Iyer,
- Wolfgang Jarolimek,
- Fiona M. Wood,
- Mark W. Fear
Affiliations
- Nutan Chaudhari
- Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia
- Alison D. Findlay
- Drug Discovery Department, Pharmaxis Ltd
- Andrew W. Stevenson
- Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia
- Tristan D. Clemons
- School of Molecular Sciences, The University of Western Australia
- Yimin Yao
- Drug Discovery Department, Pharmaxis Ltd
- Amar Joshi
- Drug Discovery Department, Pharmaxis Ltd
- Sepidar Sayar
- Intelligent Polymer Research Institute, Australian Research Council Centre of Excellence for Electromaterials Science, University of Wollongong
- Gordon Wallace
- Intelligent Polymer Research Institute, Australian Research Council Centre of Excellence for Electromaterials Science, University of Wollongong
- Suzanne Rea
- Burns Service of Western Australia, WA, Department of Health
- Priyanka Toshniwal
- Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia
- Zhenjun Deng
- Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia
- Philip E. Melton
- Menzies Institute for Medical Research, University of Tasmania
- Nicole Hortin
- Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia
- K. Swaminathan Iyer
- School of Molecular Sciences, The University of Western Australia
- Wolfgang Jarolimek
- Drug Discovery Department, Pharmaxis Ltd
- Fiona M. Wood
- Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia
- Mark W. Fear
- Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia
- DOI
- https://doi.org/10.1038/s41467-022-33148-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Scars are a significant problem caused by excess collagen in the skin. Here the authors develop a topical drug that reduces collagen stability and leads to improved scar appearance and stiffness in preclinical models.
