Nature Communications (Aug 2017)
The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning
- Victor Briz,
- Leonardo Restivo,
- Emanuela Pasciuto,
- Konrad Juczewski,
- Valentina Mercaldo,
- Adrian C. Lo,
- Pieter Baatsen,
- Natalia V. Gounko,
- Antonella Borreca,
- Tiziana Girardi,
- Rossella Luca,
- Julie Nys,
- Rogier B. Poorthuis,
- Huibert D. Mansvelder,
- Gilberto Fisone,
- Martine Ammassari-Teule,
- Lutgarde Arckens,
- Patrik Krieger,
- Rhiannon Meredith,
- Claudia Bagni
Affiliations
- Victor Briz
- KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven
- Leonardo Restivo
- Institute of Cell Biology and Neurobiology, CNR
- Emanuela Pasciuto
- KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven
- Konrad Juczewski
- Department of Neuroscience, Karolinska Institutet
- Valentina Mercaldo
- KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven
- Adrian C. Lo
- KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven
- Pieter Baatsen
- VIB Electron Microscopy Platform & Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, Department of Neurosciences KU Leuven
- Natalia V. Gounko
- VIB Electron Microscopy Platform & Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, Department of Neurosciences KU Leuven
- Antonella Borreca
- KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven
- Tiziana Girardi
- VIB Center for Brain & Disease Research, Department of Neurosciences KU Leuven
- Rossella Luca
- KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven
- Julie Nys
- KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven
- Rogier B. Poorthuis
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University
- Huibert D. Mansvelder
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University
- Gilberto Fisone
- Department of Neuroscience, Karolinska Institutet
- Martine Ammassari-Teule
- Institute of Cell Biology and Neurobiology, CNR
- Lutgarde Arckens
- Department of Biology, Laboratory of Neuroplasticity and Neuroproteomics, KU Leuven
- Patrik Krieger
- Department of Neuroscience, Karolinska Institutet
- Rhiannon Meredith
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University
- Claudia Bagni
- KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven
- DOI
- https://doi.org/10.1038/s41467-017-00311-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Brain cytoplasmic (BC1) RNA is a non-coding RNA that has been implicated in translational regulation, seizure, and anxiety. Here, the authors show that in the cortex, BC1 RNA is required for sensory deprivation-induced structural plasticity of dendritic spines, as well as for correct sensory learning and social behaviors.
