A New Macrodiolide and Two New Polycyclic Chromones from the Fungus <i>Penicillium</i> sp. SCSIO041218

Abstract

A new macrodiolide, mangrovlide A (1) and two new polycyclic chromones, penixanthones C (2) and D (3), as well as four other known compounds (4−7), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound 1 possesses a 10-membered macrodiolide unit, while 2 and 3 are chromones with an unprecedented 6/6/6/5 polycyclic skeleton. Compounds 1−7 were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.

Keywords

• marine fungus
• <i>Penicillium</i> sp.
• penixanthone
• macrodiolide
• chromone